Elimination of low molecular weight polyethylene glycol 400 in the urine following an oral load, as a measure of intestinal permeability.
نویسندگان
چکیده
After an oral load of 10 g polyethylene glycol, its concentration in the urine was measured by gas chromatography. The coefficient of variation of the imprecision between run was about 11%. The urinary excretion was 25% of the administered dose with a coefficient of variation of the interindividual variation 26% and the intraindividual variation between 13% and 29%.
منابع مشابه
The Effect of Polyethylene Glycol and Nanoclay on the Rheological Behavior of Dispersing Cationic Polyurethane Nanocomposites
Cationic waterborne polyurethane as a new dispersing polymer was synthesized by using relatively hydrophilic polyols. Dispersing cationic polyurethane (DCPU) nanocomposites were prepared using isophorone diisocyanate (IPDI), polyethylene glycol (PEG) with different molecular weights (Mn=200, 400, 600,and1000 g/mol), N-methyl diethanolamine (MDEA), dibutyltin dilaurate (DBTDL) and different perc...
متن کاملMeasurement of polyethylene glycol 400 in urine by direct-injection high-performance liquid chromatography.
We describe a new "high-performance" liquid chromatographic (HPLC) method for estimating polyethylene glycol 400 (PEG 400) in urine. Direct injection of diluted urine samples onto the column eliminates the necessity for lengthy preparative steps, resulting in considerable saving of both time and chemicals. High analytical recoveries (94-102%) and a rapid rate of analysis are achieved. Results v...
متن کاملPolyethylene glycol embedded tribromide as an efficient and reusable catalyst for the library synthesis of nitrogen containing heterocycles
Potassium tribromide wrapped around polyethylene glycol ({K+PEG400}Br3-) was easily prepared by two step reaction of PEG400 with KBr followed by the addition of molecular bromine to give PEG embedded potassium tribromide as a dark viscous oil. The synthesized material was found to be an efficient, cost effective, environmentally benig...
متن کاملEnhanced Permeability of Etoposide across Everted Sacs of Rat Small Intestine by Vitamin E-TPGS
Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat smal...
متن کاملEnhanced Permeability of Etoposide across Everted Sacs of Rat Small Intestine by Vitamin E-TPGS
Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat smal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie
دوره 19 5 شماره
صفحات -
تاریخ انتشار 1981